منابع مشابه
Proarrhythmic versus antiarrhythmic mechanisms of cardiac resynchronization therapy
Cardiac resynchronization therapy (CRT) has recently become an established therapy for patients with NYHA class III/IV systolic heart failure and prolonged QRS duration [1]. In addition to improvement in exercise capacity, NYHA symptoms class, and quality of life, evidence of the arrest or reversal of ventricular remodeling has been demonstrated [2]. A recent meta-analysis found that CRT reduce...
متن کاملPostrepolarization refractoriness versus conduction slowing caused by class I antiarrhythmic drugs: antiarrhythmic and proarrhythmic effects.
BACKGROUND Conduction block may be both antiarrhythmic and proarrhythmic. Drug-induced postrepolarization refractoriness (PRR) may prevent premature excitation and tachyarrhythmia induction. The effects of propafenone and procainamide on these parameters, and their antiarrhythmic or proarrhythmic consequences, were investigated. METHODS AND RESULTS In 11 isolated Langendorff-perfused rabbit h...
متن کاملExperimental evidence for proarrhythmic mechanisms of antiarrhythmic drugs.
The major limitation to antiarrhythmic drug therapy is the risk of arrhythmia promotion, or 'proarrhythmia.' This complication may be lethal, and greatly restricts the value of antiarrhythmic agents, particularly for arrhythmias without an intrinsic mortality risk, such as atrial fibrillation. In order for improved antiarrhythmic drug therapy to be developed, it is essential to understand the f...
متن کاملComparative study on the proarrhythmic effects of some antiarrhythmic agents.
BACKGROUND A main side effect of antiarrhythmic drug therapy is the tendency of these drugs to promote arrhythmia within the therapeutic concentration range, i.e., the proarrhythmic activity of these drugs. However, a model for in vitro assessment, quantification, and comparison of proarrhythmic drug activities was still lacking, and only sparse data were available. METHODS AND RESULTS To ana...
متن کاملProarrhythmic effects of antiarrhythmic drugs during programmed ventricular stimulation in patients without ventricular tachycardia.
The proarrhythmic effects of class IA antiarrhythmic drugs were prospectively evaluated during programmed ventricular stimulation in 24 consecutive patients with frequent ventricular premature beats whose baseline study, performed while no antiarrhythmic drugs were being taken, showed no inducible sustained ventricular arrhythmias. No patient had nonsustained (greater than 5 beats) or sustained...
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ژورنال
عنوان ژورنال: Texas Heart Institute Journal
سال: 2016
ISSN: 0730-2347,1526-6702
DOI: 10.14503/thij-16-6088